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Determination of lethal concentration (LC50) of silver nanoparticles (AgNPs) produced by chemical methods in Zebrafish (Danio rerio)
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A.R. Khiabani *   , H. Ouraji , A. Esmaeili Fereidouni |
| Department of Agriculture & Natural Resources, University of Applied Science and Technology, Tehran, Iran. |
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Abstract: (56 Views) |
| The silver nanoparticles (AgNPs) pose significant risks to aquatic ecosystems due to their persistence and toxicity, as well as challenges related to their toxicological classification and regulation. Upon release into water, AgNPs undergo oxidation, forming toxic ionic silver (Ag⁺), which exacerbates their harmful impact. To determine the lethal dose of AgNPs in this experiment, Zebrafish as a biological model animal were exposed to different concentrations of a type of colloidal AgNPs for 96 hours. Based on the results, The LC50 value for AgNPs in adult female zebrafish was determined to be 4.47 mg/L. The results showed that with increasing concentration of silver nanoparticles and also exposure time, the percentage of zebrafish mortality increased. The highest mortality rate was observed at the highest concentration of silver nanoparticles. In some treatments, fish showed signs of respiratory stress, during the hours they were exposed to AgNPs. Lower concentrations of silver nanoparticles elicited no observable behavioral alterations or mortality in the studied fish specimens. |
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| Keywords: Biological model animal, Model organism, Zebra danio, Toxicity, Biosynthesis |
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Full-Text [PDF 306 kb]
(46 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2025/04/25 | Accepted: 2025/04/30 | Published: 2025/05/17
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