Arak Mighan Wetland is one of the highest salt marshes in Iran, which is located in the center of the country at a distance of 8 kilometers to the northeast of Arak city, and it is considered one of the valuable sources of Artemia in the country. Artemia has a great nutritional value for feeding the sensitive larval and brood stages of shrimp, sturgeon, ornamental and marine fish. In this study, 18 different stations were selected in Arak Mighan lagoon with the aim of evaluating the cyst and bio mass of Artemia parthenogenetica, during March 2018 to February 2019. The amounts of cysts, nauplii, metanapulii, female and male adult Artemia present in Mighan lagoon were determined. The maximum amounts of cysts (1076 cysts per liter) and the biomass of Artemia (42.22 nauplii per liter, 412.44 metanauplii per liter, 16.22 pieces per liter of adult female Artemia and 4.22 pieces per liter of adult male Artemia) were observed in December. Appropriate management solutions for the sustainable use of these valuable reserves require further investigations, taking into account the special and unstable conditions of Mighan wetland depending on each season and year. It is recommended to create an integrated management of the Mighan Lake catchment area in order to protect the lake and its biodiversity as a unique ecological resource and ecosystem.